Jeffrey A Frost Selected Research

Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)

1/2021	Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.
1/2018	Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis.
12/2014	The RhoGEF Net1 is required for normal mammary gland development.
9/2013	Rho GTPase-independent regulation of mitotic progression by the RhoGEF Net1.
7/2013	Timing is everything: Rac1 controls Net1A localization to regulate cell adhesion.
7/2013	Regulation of focal adhesion kinase activation, breast cancer cell motility, and amoeboid invasion by the RhoA guanine nucleotide exchange factor Net1.
2/2013	Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreading.
1/2009	Coexpression of alpha6beta4 integrin and guanine nucleotide exchange factor Net1 identifies node-positive breast cancer patients at high risk for distant metastasis.

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Jeffrey A Frost Research Topics

Disease

17	Neoplasms (Cancer) 05/2021 - 12/2007
7	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2009
4	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2009
2	Pancreatic Neoplasms (Pancreatic Cancer) 05/2021 - 01/2018
2	Carcinogenesis 01/2018 - 03/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2021
1	Cachexia 01/2021
1	Herpes Zoster 01/2021
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2021
1	Neuralgia (Stump Neuralgia) 01/2019
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2019
1	Acute Pain 01/2019
1	Acromegaly 07/2018
1	Pituitary Neoplasms (Pituitary Adenoma) 07/2018
1	Pain (Aches) 01/2017
1	Chronic Pain 01/2017
1	Hypersensitivity (Allergy) 01/2017
1	Genomic Instability 05/2008

Drug/Important Bio-Agent (IBA)

8	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 01/2021 - 01/2009
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2007
2	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2021 - 03/2016
2	Hormones (Hormone)IBA 01/2021 - 01/2009
2	ezogabine (retigabine)IBA 01/2019 - 01/2017
2	Protein Isoforms (Isoforms)IBA 03/2015 - 07/2013
1	Phosphotransferases (Kinase)IBA 01/2021
1	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2021
1	4- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazoleIBA 01/2021
1	Toll-Like Receptor 4IBA 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	nilotinib FDA Link 01/2021
1	Muscle Proteins (Muscle Protein)IBA 01/2021
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2019
1	pasireotideIBA 07/2018
1	somatostatin receptor 2IBA 07/2018
1	Ion Channels (Ion Channel)IBA 07/2018
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 07/2018
1	AcidsIBA 01/2018
1	sphingosine kinaseIBA 01/2018
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2018
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2018
1	FendilineIBA 01/2018
1	PhosphatidylserinesIBA 01/2018
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2018
1	LigandsIBA 01/2016
1	Rho Guanine Nucleotide Exchange FactorsIBA 01/2016
1	Focal Adhesion Protein-Tyrosine KinasesIBA 07/2013
1	Biomarkers (Surrogate Marker)IBA 01/2009
1	Integrin alpha6beta4IBA 01/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2009
1	human ERBB2 proteinIBA 01/2009
1	Bacterial ToxinsIBA 05/2008
1	DNA (Deoxyribonucleic Acid)IBA 05/2008
1	p38 Mitogen-Activated Protein KinasesIBA 05/2008

Therapy/Procedure

1	Therapeutics 05/2021
1	Cell Transplantation 01/2018
1	Drug Therapy (Chemotherapy) 01/2009
1	Simple Mastectomy 01/2009